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Decoding theDynamic Biology of the Brain

Transforming Brain Biology into Blood-Based Insights
through Brain-Derived Circular RNA

A Multi-Pathway View of Brain Biology

The Challenge

Brain disorders are driven by complex, interconnected biological pathways, yet current biomarkers and research approaches remain focused on individual molecular signals, providing only a partial view of disease biology.

A Broader Perspective

Advancing precision neurology begins with a deeper understanding of disease biology. Brain-derived circular RNA (circRNA) provides insight across multiple biological pathways, offering a broader view of the molecular complexity underlying neurological diseases.

Learn About Brain Biology

KEY PATHWAYS

Biological P A TH W A YS
Synaptic Function
Neuroinflammation
Oxidative Stress
Proteolytic Function
Amyloid Biology
Tau Biology
Neurodegeneration
Metabolic Dysfunction

Circular RNA: A New Molecular Layer

Circular RNA represents a new molecular layer for investigating the complexity of brain biology.

Unique Biological Properties

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Brain-Derived
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Stable Structure
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Dynamic Expression
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Detected in Blood
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Multi-Pathway Biology
Watch the 2-minute Video

Translating Biology into Molecular Intelligence

Transforming Biological Signals into Clinical ResearchInsights

CircPath™ is our proprietary molecular intelligence platform, translating circular RNA into actionable biological insights.

The platform integrates signals across multiple biological pathways, providing a broader view of neurological disease and enabling new opportunities for neuroscience research.

Supporting Researchers Across the Neuroscience Ecosystem

Designed  for academic researchers, biopharma organizations, Alzheimer’s Disease Research Centers, and translational neuroscience programs.

For Research Use Only (RUO). Not intended for use in diagnostic procedures.
Explore Research Applications

Advancing Alzheimer's Disease Research

CircPath™ is designed to support research across neurodegenerative diseases, with an initial focus on Alzheimer's disease, where there is an urgent need for earlier biological insight and improved biomarkers.

Through CircPath™, Circular Genomics is advancing research applications designed to support disease detection, prediction of Alzheimer's disease (AD) progression to symptom onset, biomarker discovery, and investigation of the biological pathways assocatied with AD etiology and progression.

Built on Scientific Discovery and Collaboration

Our science is built on collaboration with leading researchers and institutions advancing neuroscience.

Scientific Foundation
Washington University Medicine

Foundational discovery of brain-derived circRNA biomarkers and the 34-circRNA Alzheimer's disease signature.

Scientific Collaborators
Henrik Zetterberg photo
Henrik Zetterberg, MD, PhD
Circular Genomics Scientific Advisory Board
Carlos Cruchaga photo
Carlos Cruchaga, PhD
Washington University School of Medicine
Tim Hohman photo
Timothy Hohman, PhD
Vanderbilt University Medical Center

The Future of Precision Neurology Will Be Built Together

Together, we can advance a broader understanding of brain biology and help shape the future of neuroscience.