CircPath™: A Platform for Precision Neurology

A molecular intelligence platform translating circRNA into biological insight.

header graphic of brain image line drawing with networking dots connected throughout the image. faint line waves stretch across the screen behind it with a cluster of networking paths and dots to the left and the right of the brain image.

What CircPath™ Enables

By translating circRNA into molecular intelligence, CircPath™ supports research applications spanning biological discovery through translational research.

Disease Understanding

Investigate the biological processes underlying neurological disease.

Biomarker Discovery

Identify and evaluate novel circRNA biomarkers associated with disease biology.

Biological Stratification

Characterize biological differences across patient populations and research cohorts.

Therapeutic Development

Support translational research, target identification, and clinical trial strategies.

Risk & Progression Research

Investigate biological patterns associated with disease progression and future risk.

CircPath™ is Circular Genomics' proprietary molecular intelligence platform that discovers, validates, and translates brain-derived circular RNA into biological insight.

Built on the unique biology of circRNA, CircPath™ provides a foundation for the next generation of precision neurology research.

1

Discover 1600+

Translating circRNA Profiles into Biological Insight
Brain illstration from birds-eye view with teal and green coloring and dots with lines connecting.

Discover 1600+ combines whole-transcriptome circRNA sequencing with pathway-level analysis, enabling researchers to investigate biological patterns across individual samples, patient populations, and longitudinal studies.

By profiling more than 1,600 brain-derived circRNAs, Discover 1600+ provides a broader view of disease biology, patient heterogeneity, and the molecular pathways underlying neurological disease.

ENABLES
Disease understanding
Biomarker discovery
Cohort characterization
Target identification
Translational research
IDEAL FOR
Academic Researchers
Biopharma
CROs
KEY FEATURES
Whole-transcriptome circRNA sequencing
1,600+ Brain-derived circRNAs
Pathway-level analysis
SCIENTIFIC FOUNDATION

Grounded in the landmark Nature Medicine publication from Washington University evaluating a 34-circRNA biomarker signature associated with future cognitive decline.

2

AD Predict

Predicting Alzheimer's Disease Symptom Onset

AD Predict is a CircPath™ research application designed to support research into future cognitive impairment and Alzheimer's disease symptom onset among cognitively unimpaired individuals.

By identifying biological patterns associated with future disease progression, AD Predict enables researchers to investigate Alzheimer's disease years before symptoms appear.

ENABLES
Prevention trial enrichment
Longitudinal cohort studies
Early intervention research
Progression risk stratification
IDEAL FOR
Biopharma
Alzheimer's Disease Research Centers
Academic Researchers
LANDMARK RESEARCH HIGHLIGHTS
Published in Nature Medicine — WashU ADRC discovery cohort
HAZARD RATIO

2.92

Hazard ratio for progression to symptomatic AD (vs. 1.81 for pTau 217)
AUC

0.87

for prediction of symptom onset within 5 years
PARTICIPANTS

688

Cognitively unimpaired individuals at baseline
3

AD Detect

Identifying Alzheimer's Disease Biology

AD Detect is a CircPath™ research application designed to identify biomarker-confirmed Alzheimer's disease biology (Amyloid and Tau) from a simple blood sample.

Supporting research across biomarker-defined patient populations, AD Detect enables cohort characterization, clinical trial enrollment, and biological subgroup analyses.

ENABLES
Clinical Trial Enrollment
Cohort Characterization
Biomarker Research
Biological Subgroup Analyses
IDEAL FOR
Biopharma
Alzheimer's Disease Research Centers
Academic Researchers
LANDMARK RESEARCH HIGHLIGHTS
Published in Nature Medicine — WashU ADRC discovery cohort
PARTICIPANTS

1,200+

across the AD continuum
AUC

0.945

Biomarker-confirmed AD (CSF Aβ42 / pTau181)
. . . . . . .

Highly Specific for AD

Near-random performance for non-AD dementias (PD, DLB, FTD)

Expanding the Future of Precision Neurology

While Alzheimer's disease is the initial focus of CircPath™, the biology of circRNA has the potential to support future research applications across a broad range of neurological and neuropsychiatric conditions.

Future Areas of Research

Parkinson's Disease
Multiple Sclerosis
Amyotrophic Lateral Sclerosis (ALS)
Frontotemporal Dementia (FTD)
Mental Health & Neuropsychiatric Disorders

Let's Advance Precision Neurology Together