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Publications & Resources

Blood-based circular RNAs for early diagnosis of Alzheimer's disease

Blood-Based Circular RNA Biomarkers Outperform Gold-Standard Tests, Enable Preclinical Risk Stratification Years Before Symptom Onset, and Open New Era in Precision Neurology

The history and function of a circular RNA

In 2024, the Nobel Prize in Physiology or Medicine was awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNAs (miRNAs), acknowledging their important role as post-transcriptional regu

February 11, 2026

Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs

Circular RNAs are backspliced, closed-loop RNAs previously believed to be noncoding by-products

A brain-enriched circRNA bloodbiomarker can predict response to SSRI antidepressants

Major Depressive Disorder (MDD) is a debilitating psychiatric disorder that currently affects more than 20% of the adult US population

February 17, 2023

Prenatal alcohol exposure results in brain region and sex-specific changes in circHomer1 expression in adult mouse brain

Circular RNAs (circRNAs) are a novel category of covalently-closed non-coding RNAs mainly derived from the back-splicing of exons or introns of protein-coding genes.

Knockdown of circHomer1 in the orbitofrontal cortex results in differential encoding of salient stimuli

CircHomer1 is an activity-dependent circular RNA (circRNA) isoform produced from back-splicing of the Homer1 transcript.

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